Article
Ablation of interaction between IL-33 and ST2+ regulatory T cells increases immune cell-mediated hepatitis and activated NK cell liver infiltration.
American journal of physiology. Gastrointestinal and liver physiology - 1 Aug 2016
Noel Gregory, Arshad Muhammad Imran, Filliol Aveline, Genet Valentine, Rauch Michel, Lucas-Clerc Catherine, Lehuen Agnès, Girard Jean-Philippe, Piquet-Pellorce Claire, Samson Michel
Abstract excerpt
The IL-33/ST2 axis plays a protective role in T-cell-mediated hepatitis, but little is known about the functional impact of endogenous IL-33 on liver immunopathology. We used IL-33-deficient mice to investigate the functional effect of endogenous IL-33 in concanavalin A (Con A)-hepatitis. IL-33(-/-) mice displayed more severe Con A liver injury than wild-type (WT) mice, consistent with a hepatoprotective effect...
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