Article

Amyloidogenic core of a human λ-III immunoglobulin light chain fibril and their germline variants probed by MAS solid state NMR

2020-10-02

Abstract excerpt

Systemic antibody light chains (AL) amyloidosis is characterized by deposition of amyloid fibrils derived from a particular antibody light chain. Cardiac involvement is a major risk factor for mortality. Using MAS solid-state NMR, we study the fibril structure of a recombinant light chain fragment corresponding to the fibril protein from patient FOR005, together with fibrils formed by protein sequence variants tha...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 596e7eea-8ad5-5aca-9adf-6a1e4410342a
DOI: 10.1101/2020.10.02.323303

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Amyloidogenic core of a human λ-III immunoglobulin light chain fibril and their germline variants probed by MAS solid state NMRDOI 10.1101/2020.10.02.323303Read

Seeded fibrils of the germline variant of human λ-III immunoglobulin light chain FOR005 have a similar core as patient fibrils with reduced stability.Semantic proximity Read

Immunoglobulin Light Chains Form an Extensive and Highly Ordered Fibril Involving the N- and C-TerminiSemantic proximity Read

MAK33 antibody light chain amyloid fibrils are similar to oligomeric precursors.Semantic proximity Read

Mechanistic insights into the aggregation pathway of the patient-derived immunoglobulin light chain variable domain protein FOR005.Semantic proximity Read

Role of Complementarity-Determining Regions 1 and 3 in Pathologic Amyloid Formation by Human Immunoglobulin κ1 Light ChainsSemantic proximity Read

Driving forces in amyloidosis: How does a light chain make a heavy heart?Semantic proximity Read

Role of mutations and post-translational modifications in systemic AL amyloidosis studied by cryo-EM.Semantic proximity Read

Role of complementarity-determining regions 1 and 3 in pathologic amyloid formation by human immunoglobulin κ1 light chainsSemantic proximity Read

Amyloid formation in light chain amyloidosis.Semantic proximity Read

Light chain mutations contribute to defining the fibril morphology in systemic AL amyloidosis.Semantic proximity Read

Molecular mechanism of amyloidogenic mutations in hypervariable regions of antibody light chains.Semantic proximity Read

Cryo-EM reveals structural breaks in a patient-derived amyloid fibril from systemic AL amyloidosis.Semantic proximity Read