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Article

MAK33 antibody light chain amyloid fibrils are similar to oligomeric precursors.

PloS one - 1 Jan 2017

Hora Manuel, Sarkar Riddhiman, Morris Vanessa, Xue Kai, Prade Elke, Harding Emma, Buchner Johannes, Reif Bernd

Abstract excerpt

Little structural information is available so far on amyloid fibrils consisting of immunoglobulin light chains. It is not understood which features of the primary sequence of the protein result in fibril formation. We report here MAS solid-state NMR studies to identify the structured core of κ-type variable domain light chain fibrils. The core contains residues of the CDR2 and the β-strands D, E, F and G of the...

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Share to Amyloid
Share to Immunoglobulin Light Chains
Share to Immunoglobulin Variable Region

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Magnetic Resonance Spectroscopy

Share to Microscopy, Electron, Transmission

Share to Protein Multimerization

Share to Protein Precursors

Share to Spectroscopy, Fourier Transform Infrared

Source

Open in PubMed Open full text

Identifiers

PMID: 28746363
DOI: 10.1371/journal.pone.0181799
PMCID: PMC5528828

Genes

CDR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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