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Article

Seeded fibrils of the germline variant of human λ-III immunoglobulin light chain FOR005 have a similar core as patient fibrils with reduced stability.

The Journal of biological chemistry - 25 Dec 2020

Pradhan Tejaswini, Annamalai Karthikeyan, Sarkar Riddhiman, Huhn Stefanie, Hegenbart Ute, Schönland Stefan, Fändrich Marcus, Reif Bernd

Abstract excerpt

Systemic antibody light chains (AL) amyloidosis is characterized by deposition of amyloid fibrils derived from a particular antibody light chain. Cardiac involvement is a major risk factor for mortality. Using MAS solid-state NMR, we studied the fibril structure of a recombinant light chain fragment corresponding to the fibril protein from patient FOR005, together with fibrils formed by protein sequence variants...

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Share to Amino Acid Sequence
Share to Amyloid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin Light Chains

Share to Models, Molecular

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Share to Nuclear Magnetic Resonance, Biomolecular

Share to Protein Conformation, beta-Strand

Share to Sequence Homology

Source

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Identifiers

PMID: 33093170
DOI: 10.1074/jbc.RA120.016006
PMCID: PMC7939468

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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