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Immunoglobulin Light Chains Form an Extensive and Highly Ordered Fibril Involving the N- and C-Termini

27 Feb 2017

Abstract excerpt

High Resolution Image Download MS PowerPoint Slide Light-chain (AL)-associated amyloidosis is a systemic disorder involving the formation and deposition of immunoglobulin AL fibrils in various bodily organs. One severe instance of AL disease is exhibited by the patient-derived variable domain (V L ) of the light chain AL-09, a 108 amino acid residue protein containing seven mutations relative to the corresponding...

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PMID: 28261692
DOI: 10.1021/acsomega.6b00494

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