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Article

Driving forces in amyloidosis: How does a light chain make a heavy heart?

The Journal of biological chemistry - 1 Jan 2000

Otzen Daniel E

Abstract excerpt

Light-chain amyloidosis (AL) is a fatal disorder wherein the immunoglobulin light chain misfolds and aggregates, leading to amyloid plaques in various organs. Patient-specific mutations in the light chain variable domain (VL) are tightly linked to amyloidosis, but how these mutations drive AL is unknown. In recent work, Rottenaicher et al. analyze five mutations found in the VL of a patient with cardiac AL. Their...

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Identifiers

PMID: 34019874
DOI: 10.1016/j.jbc.2021.100785
PMCID: PMC8191319

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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