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Article

Engineering ER-stress dependent non-conventional mRNA splicing

9 Jul 2018

Abstract excerpt

The endoplasmic reticulum (ER) protein folding capacity is balanced with the protein folding burden to prevent accumulation of un- or misfolded proteins. The ER membrane-resident kinase/RNase Ire1 maintains ER protein homeostasis through two fundamentally distinct processes. First, Ire1 can initiate a transcriptional response through a non-conventional mRNA splicing reaction to increase the ER folding capacity....

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PMID: 29985129
DOI: 10.7554/elife.35388

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