Article

Divergent Molecular Pathways for Toxicity of Selected Mutant C9ORF72-derived Dipeptide Repeats

2023-09-29

Abstract excerpt

<h4>ABSTRACT</h4> Expansion of a hexanucleotide repeat in a noncoding region of the C9ORF72 gene is responsible for a significant fraction of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) cases, but mechanisms linking mutant gene products to neuronal toxicity remain debatable. Pathogenesis was proposed to involve the production of toxic RNA species and/or accumulation of toxic dipeptide re...

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Literature Corpus work: 60e55327-db00-5143-a6c8-76bc5f627ce3
DOI: 10.1101/2023.09.28.558663

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