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<i>STAT3</i> gain-of-function mutations connect leukemia with autoimmune disease by pathological dysregulation of NKG2D <sup>hi</sup> CD8 killer T cells

2022-02-11

Abstract excerpt

<h4>SUMMARY</h4> The association between cancer and autoimmune disease is unexplained, exemplified by T-cell large granular lymphocytic leukemia (T-LGL) where gain-of-function somatic mutations in STAT3 correlate with co-existing autoimmunity. To resolve whether these mutations are the cause or consequence of CD8 clonal expansions and autoimmunity, here we analyse patients with germline STAT3 GOF syndrome and m...

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Literature Corpus work
44e297f1-2cb9-50de-be56-2310dbf0076c
DOI
10.1101/2022.02.11.480027
Open publication

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