Article

KDM6B protects T-ALL cells from NOTCH1-induced oncogenic stress

2022-11-11

Abstract excerpt

<title>Abstract</title> <p>T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematopoietic neoplasm resulting from the malignant transformation of T-cell progenitors. While activating NOTCH1 mutations are the dominant genetic drivers of T-ALL, epigenetic dysfunction plays a central role in the pathology of T-ALL and can provide alternative mechanisms to oncogenesis in lieu of or in combination with gen...

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Literature Corpus work: 7046669d-f8d4-59cd-a29e-b1e8df94952c
DOI: 10.21203/rs.3.rs-2251777/v1

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