Article

Genome-wide functional CRISPR screen reveals CDK7 as a targetable therapeutic vulnerability for head and neck cancer

2024-07-29

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Head and neck squamous cell carcinoma (HNSCC) remains a challenging prevalent lethal malignancy, with still scarce targeted therapies and rather limited clinical benefit. We conducted an optimized genome-wide functional CRISPR screen aimed at identifying actionable genetic vulnerabilities for rapid preclinical evaluation as novel targeted therapies. Cyclin-depen...

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Literature Corpus work: 594e9941-22cb-5438-89a8-1b8f06c4123f
DOI: 10.21203/rs.3.rs-4679708/v1

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