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A kinome-wide synthetic lethal CRISPR/Cas9 screen reveals that mTOR inhibition prevents adaptive resistance to CDK4/CDK6 blockade in HNSCC

2023-08-07

Abstract excerpt

The comprehensive genomic analysis of the head and neck cancer (HNSCC) oncogenome revealed frequent loss of p16 INK4A ( CDKN2A ) in most HPV negative HNSCC lesions, often concomitant with amplification of the cyclin D1 ( CCND1 ) gene locus. However, cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors as single agents have shown modest effect in the clinic, even when combined with cetuximab. The aberrant activat...

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Literature Corpus work
79e37706-3980-5280-96c2-6a1b28070aa6
DOI
10.1101/2023.08.07.552216
Open publication

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A kinome-wide synthetic lethal CRISPR/Cas9 screen reveals that mTOR inhibition prevents adaptive resistance to CDK4/CDK6 blockade in HNSCCDOI 10.1101/2023.08.07.552216
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