Article

A Genome Wide CRISPR Profiling Approach Identifies Mechanisms of Cisplatin Resistance in Head and Neck Squamous Cell Carcinoma

2024-02-20

Abstract excerpt

<h4>Background: </h4> Head and neck squamous cell carcinoma (HNSCC) is a lethal disease with poor survival rates, especially for cancers arising in the oral cavity or larynx. Cisplatin is a key chemotherapeutic for HNSCC; however poor survival rates may be partially due to cisplatin resistance observed in some HNSCCs. Here, we examined the utility of genome-wide CRISPR knockout profiling for nominating pivotal mec...

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Literature Corpus work: dd7c7257-eadb-54bb-8276-a2e6104a67f7
DOI: 10.21203/rs.3.rs-3922565/v1

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