Article
Single-nucleotide polymorphism analysis accurately predicts multiple impairments in hippocampal activity and memory performance in a murine model of idiopathic autism.
Scientific reports - 4 Jan 2025
Barón-Mendoza Isabel, Márquez Luis A, Arenas Aliesha González, Guzmán-Condado Jessica, Martínez-Rojas Vladimir A, Anguiano-Buenfil Johaly, Mejía-Hernández Montserrat, Almazán Jorge Luis, Pérez-Martínez Leonor, Pedraza-Alva Gustavo, Galván Emilio J, Zepeda Angélica
Abstract excerpt
Autism spectrum disorder (ASD) comprises alterations in brain anatomy and physiology that ultimately affect information processing and behavior. In most cases, autism is considered idiopathic, involving alterations in numerous genes whose functions are not extensively documented. We evaluated the C58/J mouse strain as an idiopathic model of ASD, emphasizing synaptic transmission as the basis of information...
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