Article

<i>Brd4::Nutm1</i> fusion gene initiates NUT carcinoma <i>in vivo</i>

2023-07-30

Abstract excerpt

Nut carcinoma (NC) is an aggressive cancer with no effective treatment. The majority (70%) of NUT carcinoma is associated with chromosome translocation events that lead to the formation of a BRD4::NUTM1 fusion gene. However, because the BRD4::NUTM1 gene is unequivocally cytotoxic when ectopically expressed in cell lines, questions remain on whether the fusion gene can initiate NC. Here, we report the first genet...

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Literature Corpus work: c16ff6c3-d796-57e4-98a0-2cda5fb7a5da
DOI: 10.1101/2023.07.29.551125

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