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Benchmarking homologous recombination deficiency algorithms for prediction of clinical outcome in ovarian cancer

2025-10-09

Abstract excerpt

Homologous recombination deficiency (HRD) is a predictive biomarker for response to platinum-based chemotherapy in ovarian cancer. In this retrospective study, we benchmarked three HRD detection algorithms - CHORD, ShallowHRD, and OvaHRDscar - alongside BRCA1/2 mutation status in a cohort of 100 patients with high-grade serous ovarian carcinoma (HGSC). HRD status was derived from whole genome sequencing of tumor/n...

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Literature Corpus work
ccd91200-b3dc-5f28-b90c-edcafc99a6e6
DOI
10.1101/2025.10.08.25337487
Open publication

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Benchmarking homologous recombination deficiency algorithms for prediction of clinical outcome in ovarian cancerDOI 10.1101/2025.10.08.25337487
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