Article

Microenvironment-Inferred Genotyping: An Exclusionary Classifier for EGFR Amplification When DNA Testing Fails

2025-12-13

Abstract excerpt

EGFR amplification occurs in approximately 40-50% of glioblastoma (GBM) cases and is critical for treatment selection [1]. However, GBM tissue samples frequently yield insufficient material for comprehensive molecular testing due to extensive necrosis and tissue quality limitations [2]. This affects thousands of patients annually in the United States [4]. We developed a microenvironment-inferred genotyping approac...

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Literature Corpus work: 5928147b-d938-5598-abc6-5ea3406b8ef5
DOI: 10.64898/2025.12.10.693431

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