Personalized Tumor-Specific Amplified DNA Junctions in Peripheral Blood of Patients with High-Grade Gliomas.

doi:10.1158/1078-0432.CCR-24-3233

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Article

Personalized Tumor-Specific Amplified DNA Junctions in Peripheral Blood of Patients with High-Grade Gliomas.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 2025

Ali Mohamed F, Riviere-Cazaux Cecile, Johnson Sarah H, Salvatori Rebecca, Penheiter Alan R, Smadbeck James B, Murphy Stephen J, Harris Faye R, McCune Lex F, Carlstrom Lucas P, Barrett Michael T, Kosari Farhad, Jones Leila A, Ida Cristiane, Borad Mitesh J, Bendok Bernard R, Quiñones-Hinojosa Alfredo, Porter Alyx B, Mrugala Maciej M, Jaeckle Kurt A, Anastasiadis Panos Z, Kizilbash Sani H, Cheville John C, Routman David M, Burns Terry C, Vasmatzis George

Abstract excerpt

PURPOSE: Monitoring disease progression in patients with high-grade gliomas (HGG) is challenging due to treatment-related changes in imaging and the requirement for neurosurgical intervention to obtain diagnostic tissue. DNA junctions in HGG often amplify oncogenes, making these DNA fragments potentially more abundant in blood than monoallelic mutations. In this study, we piloted a cell-free DNA approach for...

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Identifiers

PMID: 40019927
DOI: 10.1158/1078-0432.CCR-24-3233
PMCID: PMC12010965

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