Article
Subclonal Cancer Driver Mutations Are Prevalent in the Unresected Peritumoral Edema of Adult Diffuse Gliomas.
Cancer research - 1 Apr 2024
Underhill Hunter R, Karsy Michael, Davidson Christian J, Hellwig Sabine, Stevenson Samuel, Goold Eric A, Vincenti Sydney, Sellers Drew L, Dean Charlie, Harrison Brion E, Bronner Mary P, Colman Howard, Jensen Randy L
Abstract excerpt
Adult diffuse gliomas commonly recur regardless of therapy. As recurrence typically arises from the peritumoral edema adjacent to the resected bulk tumor, the profiling of somatic mutations from infiltrative malignant cells within this critical, unresected region could provide important insights into residual disease. A key obstacle has been the inability to distinguish between next-generation sequencing (NGS)...
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