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Article

Genetic landscape of extreme responders with anaplastic oligodendroglioma.

Oncotarget - 30 May 2017

Holdhoff Matthias, Cairncross Gregory J, Kollmeyer Thomas M, Zhang Ming, Zhang Peixin, Mehta Minesh P, Werner-Wasik Maria, Souhami Luis, Bahary Jean-Paul, Kwok Young, Hartford Alan C, Chakravarti Arnab, Yegnasubramanian Srinivasan, Vogelstein Bert, Papadopoulos Nickolas, Kinzler Kenneth, Jenkins Robert B, Bettegowda Chetan

Abstract excerpt

BACKGROUND: The NRG Oncology RTOG 9402 trial showed significant survival benefit in patients with 1p/19q co-deleted anaplastic oligodendrogliomas (AO) who received both radiation (RT) and chemotherapy (PCV regimen) versus RT alone. Substantial separation of the survival curves was only seen after 7.3 years. We aimed to determine whether there are specific genetic alterations that distinguish co-deleted AO...

Topics

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Antineoplastic Combined Chemotherapy Protocols
Biomarkers, Tumor
Brain Neoplasms
Chromosome Aberrations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Chromosomes, Human, Pair 1

Chromosomes, Human, Pair 19

Neoplasm Grading

Oligodendroglioma

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Open in PubMed Open full text

Identifiers

PMID: 28388591
DOI: 10.18632/oncotarget.16773
PMCID: PMC5482595

Genes

STS
CIC
IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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