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Unraveling anoikis in glioblastoma: insights from single-cell sequencing and prognostic modeling

26 Mar 2025

Abstract excerpt

BACKGROUND: Despite advances, Glioblastoma (GBM) treatment remains challenging due to its rapid progression and resistance to therapies. OBJECTIVES: This study aimed to investigate the role of anoikis-a mechanism by which cells evade programmed cell death upon detachment from the extracellular matrix-in GBM progression and prognosis. METHODS: Utilizing single-cell sequencing and bulk-transcriptome sequencing data...

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PMID: 40140848
DOI: 10.1186/s12935-025-03752-8

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