Article

ROBIN: A unified nanopore-based sequencing assay integrating real-time, intraoperative methylome classification and next-day comprehensive molecular brain tumour profiling for ultra-rapid tumour diagnostics

2024-09-11

Abstract excerpt

<h4>Background</h4> Advances in our technological capacity to interrogate brain tumour biology has led to the ever-increasing use of genomic sequencing in routine diagnostic decision making. Presently, brain tumours are routinely classified based on their epigenetic signatures, leading to a paradigm shift in diagnostic pathways. Such testing can be performed so rapidly using nanopore sequencing that results can be...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b23dd4c4-35d0-52d8-8899-f1ffbb3d17ed
DOI: 10.1101/2024.09.10.24313398

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ROBIN: A unified nanopore-based sequencing assay integrating real-time, intraoperative methylome classification and next-day comprehensive molecular brain tumour profiling for ultra-rapid tumour diagnosticsDOI 10.1101/2024.09.10.24313398Read

ROBIN: A unified nanopore-based assay integrating intraoperative methylome classification and next-day comprehensive profiling for ultra-rapid tumor diagnosisSemantic proximity Read

Intraoperative DNA methylation classification of brain tumors impacts neurosurgical strategySemantic proximity Read

Whole-Genome Long-Read Sequencing for Rapid Comprehensive Molecular Diagnostics of Brain TumorsSemantic proximity Read

Robust methylation‐based classification of brain tumours using nanopore sequencingSemantic proximity Read

Same-day genomic and epigenomic diagnosis of brain tumors using real-time nanopore sequencingSemantic proximity Read

Robust methylation-based classification of brain tumors using nanopore sequencingSemantic proximity Read

Nanopore sequencing from formalin-fixed paraffin-embedded specimens for copy-number profiling and methylation-based CNS tumor classificationSemantic proximity Read

Rapid-CNS<sup>2</sup>: Rapid comprehensive adaptive nanopore-sequencing of CNS tumors, a proof of concept studySemantic proximity Read

iSCORED: nanopore-based random genomic sampling for intraoperative molecular diagnosisSemantic proximity Read

The central nervous system tumor methylation classifier changes neuro-oncology practice for challenging brain tumor diagnoses and directly impacts patient careSemantic proximity Read

Classification of Brain Tumors by Nanopore Sequencing of Cell-Free DNA from Cerebrospinal Fluid.Semantic proximity Read

Molecular diagnostic tools for the World Health Organization (WHO) 2021 classification of gliomas, glioneuronal and neuronal tumors; an EANO guideline.Semantic proximity Read