Article

Zinc shapes the folding landscape of p53 and establishes a new pathway for reactivating structurally diverse p53 mutants

2020-07-23

Abstract excerpt

<h4>ABSTRACT</h4> Missense mutations in the DNA binding domain (DBD) of the p53 tumor suppressor contribute to approximately half of new cancer cases each year worldwide. A primary goal in cancer therapy is to develop drugs that rescue the transcription function of mutant p53. Here we present a thermodynamic model that quantifies and links the major pathways by which mutations inactivate p53. The model is constru...

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Literature Corpus work: 5922d5e4-87bf-5937-840b-6072e0cfac41
DOI: 10.1101/2020.07.23.217695

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