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Article

The Crystal Structure of the R280K Mutant of Human p53 Explains the Loss of DNA Binding.

International journal of molecular sciences - 13 Apr 2018

Gomes Ana Sara, Trovão Filipa, Andrade Pinheiro Benedita, Freire Filipe, Gomes Sara, Oliveira Carla, Domingues Lucília, Romão Maria João, Saraiva Lucília, Carvalho Ana Luísa

Abstract excerpt

The p53 tumor suppressor is widely found to be mutated in human cancer. This protein is regarded as a molecular hub regulating different cell responses, namely cell death. Compelling data have demonstrated that the impairment of p53 activity correlates with tumor development and maintenance. For these reasons, the reactivation of p53 function is regarded as a promising strategy to halt cancer. In the present...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29652801
DOI: 10.3390/ijms19041184
PMCID: PMC5979565

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