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Article

FDA-Approved Drug Repurposing as p53 Mutants Rescue Candidates Using Structure-Based Virtual Screening and Molecular Simulations.

International journal of molecular sciences - 27 Jul 2026

Abdelsayed Mena, Boulaamane Yassir

Abstract excerpt

The restoration of mutant p53 stability is a highly sought-after strategy in targeted cancer therapy. This study presents a structure-based virtual screening and molecular dynamics approach to nominate FDA-approved drugs as candidate stabilizers of mutant p53 for downstream experimental validation. A virtual screening library of FDA-approved compounds was docked against three representative p53 mutants (7DHY,...

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Identifiers

PMID: 42589334
DOI: 10.3390/ijms27156677
PMCID: PMC13466752

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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