Drug discovery and mutant p53.

Abstract excerpt

Missense mutations in the p53 gene are commonly selected for in developing human cancer cells. These diverse mutations in p53 can inactivate its normal sequence-specific DNA-binding and transactivation function, but these mutations can also stabilize a mutant form of p53 with pro-oncogenic potential. Recent multi-disciplinary advances have demonstrated exciting and unexpected potential in therapeutically...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Drug Discovery
• Share to MDM2 gene
• Share to Mutation