Article

High glucose aggravates lipid deposition in glomerular endothelial cells by LXRs/LncRNAOR13C9/ABCA1 pathway

2020-03-19

Abstract excerpt

<title>Abstract</title> <p>Background Lipid metabolism disorder is closely related to diabetic nephropathy (DN), but the mechanism remains unclear. The aim of this study was to investigate the effect of high glucose on intracellular accumulation of lipids and to clarify the possible mechanism. Methods We found that in human glomerular endothelial cells (GEnCs), cholesterol could reduce cell activity, lead to abno...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 72dde788-dddb-5255-bdd1-7c95b12a3b60
DOI: 10.21203/rs.3.rs-17912/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

High glucose aggravates lipid deposition in glomerular endothelial cells by LXRs/LncRNAOR13C9/ABCA1 pathwayDOI 10.21203/rs.3.rs-17912/v1Read

Renal microvascular damaged in diabetes mellitus with hyperlipidemia through the regulation of MAMs by PACS2 in endothelial cellSemantic proximity Read

Association Between Blood Lipid Profile and the Incident CKD in the General Chinese Population: A Retrospective StudySemantic proximity Read

Unexplained reciprocal regulation of diabetes and lipoproteins.Semantic proximity Read

Key circRNAs, lncRNAs, and mRNAs of ShenQi Compound in protecting vascular endothelial cells from high glucose identified by whole transcriptome sequencingSemantic proximity Read

Signaling pathways of apoE and its role of gene expression in glomerulus diseasesSemantic proximity Read

[Expression mechanisms and incident factors of diabetic nephropathy].Semantic proximity Read

Transcriptional analysis reveals that the intracellular lipid accumulation impairs gene expression profiles involved in insulin response-associated cardiac functionalitySemantic proximity Read

Asprosin Promotes High Glucose-Induced Apoptosis of Human Renal Tubular Epithelial Cells by Inhibiting AutophagySemantic proximity Read

PACS-2 deficiency in tubular cells aggravates lipid-related kidney injury in diabetic kidney diseaseSemantic proximity Read

Rosuvastatin Ameliorates High Glucose-induced Endothelial Cell Dysfunction through HIF-1 ActivationSemantic proximity Read

The association between dyslipidemia and the incidence of chronic kidney disease in the general Zhejiang population: a retrospective studySemantic proximity Read

EPC-EXs Improve Neuronal Survival and Oxidative Stress Through Different Uptaking Pathways in Diabetic Hypoxia ConditionSemantic proximity Read