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Article

BACH1 deficiency improves placental angiogenesis via SLC25A51-mediated mitochondrial NAD+ transport in intrahepatic cholestasis of pregnancy

1 May 2025

Abstract excerpt

Abstract Background Placental angiogenesis is particularly important in the treatment of intrahepatic cholestasis of pregnancy (ICP). Although BACH1 has been implicated in angiogenesis associated with cardiovascular diseases, its specific role and underlying mechanisms in ICP remain unclear. This study aims to investigate the role of BACH1 in ICP. Methods The study used clinical samples and two distinct mouse...

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PMID: 40312332
DOI: 10.1186/s10020-025-01215-4

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