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Article

The double-edged role of FASII regulator FabT in Streptococcus pyogenes infection.

Nature communications - 4 Oct 2024

Lambert Clara, Gaillard Marine, Wongdontree Paprapach, Bachmann Caroline, Hautcoeur Antoine, Gloux Karine, Guilbert Thomas, Méhats Celine, Prost Bastien, Solgadi Audrey, Abreu Sonia, Andrieu Muriel, Poyart Claire, Gruss Alexandra, Fouet Agnes

Abstract excerpt

In Streptococcus pyogenes, the type II fatty acid (FA) synthesis pathway FASII is feedback-controlled by the FabT repressor bound to an acyl-Acyl carrier protein. Although FabT defects confer reduced virulence in animal models, spontaneous fabT mutants arise in vivo. We resolved this paradox by characterizing the conditions and mechanisms requiring FabT activity, and those promoting fabT mutant emergence. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39366941
DOI: 10.1038/s41467-024-52637-3
PMCID: PMC11452403

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