Article
Genomic Landscape of Intrahost Variation in Group A Streptococcus: Repeated and Abundant Mutational Inactivation of the fabT Gene Encoding a Regulator of Fatty Acid Synthesis.
Infection and immunity - 1 Dec 2016
Eraso Jesus M, Olsen Randall J, Beres Stephen B, Kachroo Priyanka, Porter Adeline R, Nasser Waleed, Bernard Paul E, DeLeo Frank R, Musser James M
Abstract excerpt
To obtain new information about Streptococcus pyogenes intrahost genetic variation during invasive infection, we sequenced the genomes of 2,954 serotype M1 strains recovered from a nonhuman primate experimental model of necrotizing fasciitis. A total of 644 strains (21.8%) acquired polymorphisms relative to the input parental strain. The fabT gene, encoding a transcriptional regulator of fatty acid biosynthesis...
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