Screening in serum-derived medium reveals differential response to compounds targeting metabolism

Abstract excerpt

<h4>SUMMARY</h4> A challenge for screening new candidate drugs to treat cancer is that efficacy in cell culture models is not always predictive of efficacy in patients. One limitation of standard cell culture is a reliance on non-physiological nutrient levels to propagate cells. Which nutrients are available can influence how cancer cells use metabolism to proliferate and impact sensitivity to some drugs, but a g...

Topics

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• 3D Printing in Biomedical Research
• Cancer Cells and Metastasis
• Cancer, Hypoxia, and Metabolism
• Cell Proliferation
• Metabolic Networks and Pathways
• Mutation
• Neoplasms
• Phenotype

Identifiers and source

Literature Corpus work

58f9f86d-93f5-513d-8d5e-3045d99a3190

DOI

10.1101/2023.02.25.529972