Article
Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides.
Nature - 3 Apr 2014
Birsoy Kıvanç, Possemato Richard, Lorbeer Franziska K, Bayraktar Erol C, Thiru Prathapan, Yucel Burcu, Wang Tim, Chen Walter W, Clish Clary B, Sabatini David M
Abstract excerpt
As the concentrations of highly consumed nutrients, particularly glucose, are generally lower in tumours than in normal tissues, cancer cells must adapt their metabolism to the tumour microenvironment. A better understanding of these adaptations might reveal cancer cell liabilities that can be exploited for therapeutic benefit. Here we developed a continuous-flow culture apparatus (Nutrostat) for maintaining...
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