Article
The landscape of metabolic pathway dependencies in cancer cell lines
2020-10-07
Abstract excerpt
The metabolic reprogramming of cancer cells creates metabolic vulnerabilities that can be therapeutically targeted. However, our understanding of metabolic dependencies and the pathway crosstalk that creates these vulnerabilities in cancer cells remains incomplete. Here, by integrating gene expression data with genetic loss-of-function and pharmacological screening data from hundreds of cancer cell lines, we ident...
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Identifiers and source
- Literature Corpus work
- 6b9bcc0e-7df6-5f52-910d-1fa4d1adaafd
- DOI
- 10.1101/2020.10.05.327429