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Decoding Duchenne muscular dystrophy transcriptome to single nuclei level reveals clinical-genetic correlations

2023-03-03

Abstract excerpt

The cellular and molecular consequences of lack of dystrophin in humans are only partially known, which is crucial for the development of new therapies aiming to slow or stop the progression Duchenne and Becker muscular dystrophies. We analyzed muscle biopsies of DMD patients and controls using single nuclei RNA sequencing (snRNAseq) and correlated the results with clinical data. DMD samples displayed an increase...

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Literature Corpus work
455de590-7b88-5726-b9e0-141c2ab56f0a
DOI
10.1101/2023.03.01.530728
Open publication

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Decoding Duchenne muscular dystrophy transcriptome to single nuclei level reveals clinical-genetic correlationsDOI 10.1101/2023.03.01.530728
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