Article

Distinct myofibre domains of the human myotendinous junction revealed by single nucleus RNA-seq

2022-12-17

Abstract excerpt

The myotendinous junction (MTJ) is a specialized domain of the multinucleated myofibre, faced with the challenge of maintaining robust cell-matrix contact with the tendon under high mechanical stress and strain. Here, we profiled 24,161 nuclei in semitendinosus muscle-tendon samples from 3 healthy males by single nucleus RNA-sequencing (snRNA-seq), alongside spatial transcriptomics, to gain insight into the genes...

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Literature Corpus work: dccc1106-3709-5bd4-b351-d341eaf0b413
DOI: 10.1101/2022.12.16.519020

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