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Building and re-building the heart by cardiomyocyte proliferation

1 Mar 2016

Abstract excerpt

The adult human heart does not regenerate significant amounts of lost tissue after injury. Rather than making new, functional muscle, human hearts are prone to scarring and hypertrophy, which can often lead to fatal arrhythmias and heart failure. The most-cited basis of this ineffective cardiac regeneration in mammals is the low proliferative capacity of adult cardiomyocytes. However, mammalian cardiomyocytes can...

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PMID: 26932668
DOI: 10.1242/dev.132910

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