Article
RAS/MAPK Activation Is Associated with Reduced Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer: Therapeutic Cooperation Between MEK and PD-1/PD-L1 Immune Checkpoint Inhibitors.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Mar 2016
Loi Sherene, Dushyanthen Sathana, Beavis Paul A, Salgado Roberto, Denkert Carsten, Savas Peter, Combs Susan, Rimm David L, Giltnane Jennifer M, Estrada Monica V, Sánchez Violeta, Sanders Melinda E, Cook Rebecca S, Pilkinton Mark A, Mallal Simon A, Wang Kai, Miller Vincent A, Stephens Phil J, Yelensky Roman, Doimi Franco D, Gómez Henry, Ryzhov Sergey V, Darcy Phillip K, Arteaga Carlos L, Balko Justin M
Abstract excerpt
PURPOSE: Tumor-infiltrating lymphocytes (TIL) in the residual disease (RD) of triple-negative breast cancers (TNBC) after neoadjuvant chemotherapy (NAC) are associated with improved survival, but insight into tumor cell-autonomous molecular pathways affecting these features are lacking. EXPERIMENTAL DESIGN: We analyzed TILs in the RD of clinically and molecularly characterized TNBCs after NAC and explored...
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