Recording γ-secretase activity in living mouse brains

Abstract excerpt

γ-Secretase plays a pivotal role in the central nervous system. Our recent development of genetically encoded Förster resonance energy transfer (FRET)-based biosensors has enabled the spatiotemporal recording of γ-secretase activity on a cell-by-cell basis in live neurons in culture . Nevertheless, how γ-secretase activity is regulated in vivo remains unclear. Here we employ the near-infrared (NIR) C99 720-670 b...

Topics

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• Alzheimer Disease
• Amino Acid Motifs
• Amyloid beta-Peptides
• Amyloid Precursor Protein Secretases
• Biosensing Techniques
• Mutation
• Presenilin-1
• Protein Conformation

Identifiers and source

Literature Corpus work

58e2e092-245a-5bef-bbb4-3e65b01e66bb

DOI

10.1101/2024.01.31.578105