Genetically encoded biosensor for fluorescence lifetime imaging of PTEN dynamics in the intact brain

Abstract excerpt

The phosphatase and tensin homolog (PTEN) is a vital signaling protein which maintains an inhibitory brake that is critical for cellular metabolism, proliferation, and growth. The importance of PTEN signaling is evident from the broad spectrum of human pathologies associated with its loss of function. Moreover, loss or gain of PTEN function in animal models leads to aberrant cellular morphology, function, and meta...

Topics

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• Autistic Disorder
• Genetic Variation
• Models, Molecular
• Neoplasms
• Protein Conformation
• Protein Stability
• Protein Unfolding
• PTEN Phosphohydrolase

Identifiers and source

Literature Corpus work

52ed5bb2-676f-584e-8dce-683e4a0a8141

DOI

10.1101/2024.10.04.616644