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Article

A luciferase prosubstrate and a red bioluminescent calcium indicator to image neuronal activity

2021-12-07

Abstract excerpt

Genetically encoded fluorescent indicators have been broadly used to monitor neuronal activity in live animals, but invasive surgical procedures are required. This study presents a functional bioluminescence imaging (fBLI) method for recording the activity of neuronal ensembles in the brain in awake mice. We developed a luciferase prosubstrate activatable in vivo by nonspecific esterase to enhance the brain deliv...

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Identifiers and source

Literature Corpus work
5dfa357d-9622-575f-b38d-c1c90bcb6c8a
DOI
10.1101/2021.12.06.471018
Open publication

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A luciferase prosubstrate and a red bioluminescent calcium indicator to image neuronal activityDOI 10.1101/2021.12.06.471018
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