Article

“Frustratingly easy” domain adaptation for cross-species transcription factor binding prediction

2025-05-26

Abstract excerpt

<h4>Motivation</h4> Understanding how DNA sequence encodes gene regulation remains a central challenge in genomics. While deep learning models can predict regulatory activity from sequence with high accuracy, their generalizability across species—and thus their ability to capture fundamental biological principles—remains limited. Cross-species prediction provides a powerful test of model robustness and offers a w...

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Literature Corpus work: d3045fb4-e67f-5eb2-9ec9-7a74f30951a3
DOI: 10.1101/2025.05.21.655414

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