Article

A recurrent pathogenic <i>BRCA2</i> truncating variant reveals a role for BRCA2-PCAF complex in modulating NF-κB-driven transcription

2025-05-13

Abstract excerpt

<h4>Summary</h4> Germline monoallelic truncating mutations in BRCA2, a critical mediator of homologous recombination (HR), predispose individuals to breast and ovarian cancer. While tumorigenesis is usually attributed to biallelic inactivation, emerging evidence suggests that haploinsufficiency may suffice in certain contexts. To investigate this, we recreated two BRCA2 pathogenic truncating variants in heterozy...

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Literature Corpus work: 82c4814b-8db7-544d-a12c-4fb03a09a25a
DOI: 10.1101/2025.05.12.652853

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