Back to search

Article

Chromatin signalling pathways and FANCE amplification affect ATR inhibitor sensitivity in metastatic breast cancer

2025-08-31

Abstract excerpt

<h4>ABSTRACT</h4> Metastatic breast cancer remains incurable, as many patients develop therapy resistance. Loss of ATM/p53 increases reliance on the ATR pathway, positioning ATR inhibitors (ATRi) as promising therapeutics. However, targeting a single pathway often leads to resistance due to tumour heterogeneity or alternative signalling mechanisms. Here, we combine chromatin-enrichment proteomics and phospho-prot...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
0a8e8c90-218b-5bd8-9643-f5efa47040be
DOI
10.1101/2025.08.26.672363
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Chromatin signalling pathways and FANCE amplification affect ATR inhibitor sensitivity in metastatic breast cancerDOI 10.1101/2025.08.26.672363
Chemo-Phosphoproteomic Profiling with ATR Inhibitors Berzosertib and Gartisertib Uncovers New Biomarkers and DNA Damage Response RegulatorsSemantic proximity
The genomic landscape of intrinsic and acquired resistance to cyclin-dependent kinase 4/6 inhibitors in patients with hormone receptor positive metastatic breast cancerSemantic proximity
Molecular portraits of cell cycle checkpoint kinases in cancer evolution, progression, and treatment responsiveness.Semantic proximity
Molecular portraits of cell cycle checkpoint kinases in cancer evolution, progression, and treatment responsivenessSemantic proximity
Longitudinal and multimodal auditing of tumor adaptation to CDK4/6 inhibitors in HR+ metastatic breast cancersSemantic proximity
The FANCM-RMI1/2 complex promotes genomic instability and PARP inhibitor sensitivity in BRCA2-deficicient cellsSemantic proximity
BRCA1 RING Function Is Essential for Tumor Suppression but Dispensable for Therapy ResistanceSemantic proximity
Mutational and functional heterogeneity of homology-directed repair deficiency and clinical implicationsSemantic proximity
Integrated Multi-Omics and Interactome Analysis of CDK8 Inhibition Reveals Erythroid Differentiation Programs and BET Synergy in AML Stem-like CellsSemantic proximity
CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCISemantic proximity
ATR and PKMYT1 inhibition re-sensitize a subset of TNBC patient-derived models to carboplatin inducing mitotic catastropheSemantic proximity
The phosphoproteomic landscape of the DNA damage responseSemantic proximity
Select a neighboring publication to make it the new centre.