Article

Relationship of Cytochrome P450 Gene Polymorphisms With Blood Concentration of Hydroxychloroquine and Its Metabolites and Adverse Drug Reactions

2021-10-29

Abstract excerpt

<h4>Background: </h4> Hydroxychloroquine (HCQ) is a cornerstone therapy for systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). This study aimed to investigate the relationship of cytochrome P450 (CYP450) gene polymorphisms with blood concentration of HCQ and its metabolites and adverse drug reactions (ADRs) in patients with SLE and RA. <h4>Methods: </h4> A cohort of 146 patients with SLE and RA trea...

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Literature Corpus work: 58901c4a-5a70-5002-bc29-0aec62c813f9
DOI: 10.21203/rs.3.rs-1010781/v1

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