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Article

Relationship of cytochrome P450 gene polymorphisms with blood concentrations of hydroxychloroquine and its metabolites and adverse drug reactions.

BMC medical genomics - 8 Feb 2022

Gao Beibei, Tan Tingfei, Cao Xi, Pan Menglu, Yang Chunlan, Wang Jianxiong, Shuai Zongwen, Xia Quan

Abstract excerpt

BACKGROUND: Hydroxychloroquine (HCQ) is a cornerstone therapy for systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). This study aimed to investigate the relationship of cytochrome P450 (CYP450) gene polymorphisms with blood concentrations of HCQ and its metabolites and adverse drug reactions (ADRs) in patients with SLE and RA. METHODS: A cohort of 146 patients with SLE and RA treated with HCQ was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 Enzyme System

Share to Drug-Related Side Effects and Adverse Reactions

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Share to Lupus Erythematosus, Systemic

Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 35135554
DOI: 10.1186/s12920-022-01171-6
PMCID: PMC8822703

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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