Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genotype-guided new approach for dose optimisation of hydroxychloroquine administration in Chinese patients with SLE.

Lupus science & medicine - 22 Nov 2023

Xie Han, Wen Xin, Wang Yuchun, Huang Xuan, Shu Qing, Wang Dandan, Geng Linyu, Jin Ziyi, Shen Wei, Ge Weihong, Zhu Yizhun, Sun Lingyun

Abstract excerpt

OBJECTIVES: The study aims to investigate the impact of gene polymorphisms on blood hydroxychloroquine (HCQ) concentrations in patients with SLE and provide guidelines for individualised care. METHODS: 489 Chinese patients with SLE taking HCQ for more than 3 months were collected in this study. The blood HCQ, desethylhydroxychloroquine (DHCQ) and desethylchloroquine concentrations were measured. The optimal blood...

Topics

Join the communities discussing this publication.

Antirheumatic Agents
Cytochrome P-450 CYP2C8
Cytochrome P-450 CYP2D6
East Asian People
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hydroxychloroquine

Lupus Erythematosus, Systemic

Source

Open in PubMed Open full text

Identifiers

PMID: 37993281
DOI: 10.1136/lupus-2023-000997
PMCID: PMC10668244

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Genotype-guided new approach for dose optimisation of hydroxychloroquine administration in Chinese patients with SLE.PMID 37993281Read ↗

The DHCQ/HCQ metabolic ratio and CYP2C8 Genotype are associated with lipid profile improvement in systemic lupus erythematosus patients treated with hydroxychloroquine.Semantic proximity Read ↗

Association of Polymorphisms of Cytochrome P450 2D6 With Blood Hydroxychloroquine Levels in Patients With Systemic Lupus Erythematosus.Semantic proximity Read ↗

Relationship of Cytochrome P450 Gene Polymorphisms With Blood Concentration of Hydroxychloroquine and Its Metabolites and Adverse Drug ReactionsSemantic proximity Read ↗

Relationship of cytochrome P450 gene polymorphisms with blood concentrations of hydroxychloroquine and its metabolites and adverse drug reactions.Semantic proximity Read ↗

Genetic markers in CYP2C19 and CYP2B6 for prediction of cyclophosphamide's 4-hydroxylation, efficacy and side effects in Chinese patients with systemic lupus erythematosus.Semantic proximity Read ↗

Clinical and pharmacogenetic influences on response to hydroxychloroquine in discoid lupus erythematosus: a retrospective cohort study.Semantic proximity Read ↗

Dosage optimization of tacrolimus based on the glucocorticoid dose and pharmacogenetics in adult patients with systemic lupus erythematosus.Semantic proximity Read ↗

Associations of HSP90AA2 gene polymorphisms with disease susceptibility, glucocorticoids efficacy and health-related quality of life in Chinese systemic lupus erythematosus patients.Semantic proximity Read ↗

Frequency and impact of DHODH, ABCG2 and CYP2C19 SNPs on the therapeutic efficacy, tolerability and toxicity of leflunomide.Semantic proximity Read ↗

The haze around pharmacokinetics of hydroxychloroquineSemantic proximity Read ↗

Dihydroorotate dehydrogenase polymorphism influences the toxicity of leflunomide treatment in patients with rheumatoid arthritisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.