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Article

Clinical and pharmacogenetic influences on response to hydroxychloroquine in discoid lupus erythematosus: a retrospective cohort study.

The Journal of investigative dermatology - 1 Oct 2011

Wahie Shyamal, Daly Ann K, Cordell Heather J, Goodfield Mark J, Jones Stephen K, Lovell Christopher R, Carmichael Andrew J, Carr Mary M, Drummond Angela, Natarajan Sivakumar, Smith Catherine H, Reynolds Nick J, Meggitt Simon J

Abstract excerpt

The recommended systemic therapy of choice for discoid lupus erythematosus (DLE) is the 4-aminoquinolone antimalarial hydroxychloroquine. There is limited published information on the likelihood of clinical response and, in particular, what factors influence outcome. We conducted a multicenter observational and pharmacogenetic study of 200 patients with DLE treated with hydroxychloroquine. The primary outcome was...

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Identifiers

PMID: 21734714
DOI: 10.1038/jid.2011.167

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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