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Association of Polymorphisms of Cytochrome P450 2D6 With Blood Hydroxychloroquine Levels in Patients With Systemic Lupus Erythematosus.

Arthritis & rheumatology (Hoboken, N.J.) - 1 Jan 2016

Lee Ji Yeon, Vinayagamoorthy Nadimuthu, Han Kyungdo, Kwok Seung Ki, Ju Ji Hyeon, Park Kyung Su, Jung Seung-Hyun, Park Sung-Won, Chung Yeun-Jun, Park Sung-Hwan

Abstract excerpt

OBJECTIVE: To evaluate associations of genetic polymorphisms in cytochrome P450 (CYP) isoforms 2D6, 3A5, and 3A4 with blood concentrations of hydroxychloroquine (HCQ) and its metabolite, N-desethyl HCQ (DHCQ), in patients with systemic lupus erythematosus (SLE). METHODS: SLE patients taking HCQ for >3 months were recruited and were genotyped for 4 single-nucleotide polymorphisms in CYP2D6*10, CYP3A5*3, and...

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Antirheumatic Agents
Asian People
Cytochrome P-450 CYP2D6
Cytochrome P-450 CYP3A
Gene Frequency

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hydroxychloroquine

Lupus Erythematosus, Systemic

Polymorphism, Genetic

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PMID: 26316040
DOI: 10.1002/art.39402

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