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The DHCQ/HCQ metabolic ratio and CYP2C8 Genotype are associated with lipid profile improvement in systemic lupus erythematosus patients treated with hydroxychloroquine.

Arthritis research & therapy - 17 Apr 2026

Zhao Xue, Xie Han, Shao Tengfei, Ge Weihong, Zhu Yizhun, Jin Ziyi, Sun Lingyun

Abstract excerpt

BACKGROUND: Hydroxychloroquine (HCQ) improves the lipid profile in patients with systemic lupus erythematosus (SLE). Whether the lipid profile-improving efficacy of HCQ relates to its metabolism by cytochrome P450 (CYP450) enzymes remains unclear. METHODS: In this prospective cohort study, 459 Chinese adult patients with SLE who had received stable HCQ therapy for at least 3 months were enrolled. The whole‑blood...

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Antirheumatic Agents
Cytochrome P-450 CYP2C8
Genotype
Hydroxychloroquine
Lipids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lupus Erythematosus, Systemic

Polymorphism, Single Nucleotide

Treatment Outcome

Source

Open in PubMed Open full text

Identifiers

PMID: 41998749
DOI: 10.1186/s13075-026-03813-x
PMCID: PMC13220571

Genes

CYP2C8
CYP3A4
CYP3A5
TG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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