Article

RAS activation via CRLF2 signaling is a widespread mechanism in Down syndrome acute lymphoblastic leukemia regardless of RAS mutations

2020-02-03

Abstract excerpt

<h4>Background</h4> Down syndrome acute lymphoblastic leukemia (DS-ALL) is characterized by the high frequency of CRLF2-rearrangements, JAK2-mutations, or RAS-pathway mutations. Intriguingly, JAK2 and RAS mutations are mutually exclusive in leukemic sub-clones, causing dichotomy in therapeutic target choices. <h4>Results</h4> Here we show that in primary leukemic cells from DS-ALL, in the absence of RAS-mutation...

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Literature Corpus work: 585d6a36-18b6-5b84-b84c-e9ec51f5be0c
DOI: 10.1101/2020.02.03.931725

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